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Researchers discovered that participants investing in this drug for any year, dropped excess weight within one month and have kept the weight off through the 56 weeks with the study. Contrave is often a combination in the drugs naltrexone and bupropion, which seems to reflect a new trend of weight-loss drugs that are made up of more than one active ingredient, that might make them more effective and safer.

Combo-pilling is the newest fad or better yet the newest to come under scrutiny and therefore it is just more publicly known lately, comb-pilling for weight loss has been around since the eighties. The biggest reason that employing a combination of pills is becoming popular will be the fact that since right now there aren't any long term prescription weightloss pills that have been licensed by the FDA other than orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications however some of the combinations have been rejected or have yet to be licensed by the FDA.

Seizures certainly are a side effect with Contrave and must not be taken in those with seizure disorders. The drug may also raise hypertension and heartbeat, and shouldn't be used in individuals with a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy with the drug.

The FDA also warned that Contrave can raise blood pressure level and heartrate and must not used in patients with uncontrolled high blood pressure levels, in addition to by anyone with heart-related and cerebrovascular (blood vessel dysfunction impacting mental performance) disease. Patients using a history of cardiac arrest or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes which has a boxed warning to alert medical researchers and patients on the increased likelihood of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for smoking cessation.


The most common unwanted side effects with Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.
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